Guaiacol O-acetylsalicylate
Guacetisal
CAS: 55482-89-8
Molecular Formula: C16H14O5
Guaiacol O-acetylsalicylate - Names and Identifiers
| Name | Guacetisal |
| Synonyms | Guaiaspir 259-663-1 55482-89-8 guacetisal Guacetisal GUACETISALUM Guacetisal (Aspirin) Guaiacol O-acetylsalicylate 2-Methoxyphenyl 2-acetoxybenzoate 2-Methoxyphenyl 2-acetoxy-benzoate 2-methoxyphenyl 2-(acetyloxy)benzoate 2-(Acetyloxy)benzoic Acid 2-Methoxyphenyl Ester 2-Acetyloxybenzenecarboxylic acid 2-methoxyphenyl ester |
| CAS | 55482-89-8 |
| EINECS | 259-663-1 |
| InChI | InChI=1/C16H14O5/c1-11(17)20-13-8-4-3-7-12(13)16(18)21-15-10-6-5-9-14(15)19-2/h3-10H,1-2H3 |
Guaiacol O-acetylsalicylate - Physico-chemical Properties
| Molecular Formula | C16H14O5 |
| Molar Mass | 286.28 |
| Density | 1.220±0.06 g/cm3(Predicted) |
| Melting Point | 71-73 °C(Solv: ethanol (64-17-5)) |
| Boling Point | 463.8±30.0 °C(Predicted) |
| Flash Point | 207.2°C |
| Vapor Presure | 8.84E-09mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.56 |
| Physical and Chemical Properties | White crystalline powder, a few odorless, tasteless. Melting Point 74-74.5 °c. |
| Use | Used as an anti-inflammatory analgesic |
Guaiacol O-acetylsalicylate - Upstream Downstream Industry
| Raw Materials | Guaiacol |
Guaiacol O-acetylsalicylate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.493 ml | 17.465 ml | 34.931 ml |
| 5 mM | 0.699 ml | 3.493 ml | 6.986 ml |
| 10 mM | 0.349 ml | 1.747 ml | 3.493 ml |
| 5 mM | 0.07 ml | 0.349 ml | 0.699 ml |
Last Update：2024-01-02 23:10:35
Guaiacol O-acetylsalicylate - Reference Information
| biological activity | Guacetisal is produced by the esterification reaction of acetylsalicylic acid acetate with guaiacol, which has the potential to be used in the study of chronic bronchitis, from Patent CN 106866420 A. |
| Use | has the effect of delaying bradykinin to make tracheal spasm, and expectorant, Antiasthmatic, antitussive, anti-inflammatory and antipyretic effects. For influenza, cold of the trachea and bronchitis, pulmonary complications and acute and chronic respiratory catarrhal lesions with or without Fever, pain inflammation treatment. used as anti-inflammatory analgesic |
| production method | salicylic acid and guaiacol are mixed, and a small amount of phosphorus oxychloride is slowly added dropwise under stirring at 95~105 ℃, reaction was added. While hot, it was poured into water, washed several times, and the aqueous layer was separated. 20% sodium carbonate was added, adjusted to Ph = 7.5-8, washed with warm water until the Ph was about 7, and cooled to normal temperature. The solid was placed, filtered and recrystallized from ethanol to obtain guaiacol salicylate with a melting point of 68-70 ° C. And a yield of 49.8%. Salicylic acid guaiacol Ester and acetic anhydride and the catalytic amount of concentrated sulfuric acid mixed at 60 deg C reaction. Ice-saline was dropped with stirring and allowed to stand. The crystals were collected by filtration, washed with water until neutral, and recrystallized from ethanol to give quetiapine, melting point 72~74.5 ℃, yield 88%. |
Last Update：2024-04-09 21:01:54
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Raw Materials for Guaiacol O-acetylsalicylate